The Department of Biotechnology invites Expression of Interest focusing on 'Cancer associated Cachexia, Pain and Anemia' as a part of Cancer Disease Biology program under its 'Health, Wellness and Medical Intervention' Directorare. The EoI on various
Eligibility
- Either candidate from recognized Academic institutions/Universities/ R&D
centres recognized by DSIR:
- Basic Scientist
- Clinicals
- Biotechnologists
- Clinical Researchers
- Minimum requirement for submission of EoI:
- A Project Coordinator should be identified
- The investigators must hold a regular position in an academic
institution/organization in India
- The proposal should have clear objectives, rationale, clearly specified
deliverables and a brief work plan
- The role of each collaborator must be complementary in nature rather than
repetitive
- Applications from individual researchers are not eligible.
- Each applicant (investigator) can be part of only one (1) Expression of
Interest
How to apply
- Candidate need to choose one topic and subtopic from given theme and submit the proposal.
- Candidate need to email EoI to nsrivastava.dbt@nic.in in single PDF File and a Word File (8 to 12 pages).
- The EoI should be signed by all the PI(s)/Co-PI(s), Project Coordinator and
forwarded by the Executive Head of the proposed host
institution(s)/organization(s)
- The following format for EoI should be followed:
- Proposal Title
- Specific Priority Area of your proposal: (Cachexia/Pain/Anemia)
- Name of the Project Coordinator, Affiliation and contact details
- Details of institutions and investigators involved in project
- Scientific Rational /hypothesis
- Clear goals and objectives
- Brief strategy to execute the targeted goals alongwith work plan
- Expected outcomes/deliverables
- A graphical abstract/infographic in the form of 3-4 ppt slides of the
proposed study (to be enclosed separately as ppt/pptx file)
- Role & responsibility of each collaborating partner
- Brief CV (1 page) of Project Coordinator/collaborating PI/Co-PIs
- Details of Publications strictly related to the proposed topic
- Approximate Budgetary requirement to accomplish the targeted goals
| Topic (Either one) | Subtopic of Proposal (Either one) |
| Cancer Cachexia | - The identification of early biomarkers for cancer cachexia
- The role of gut inflammation, the microbiome, and gut hormones in the
- The role of gut inflammation, the microbiome, and gut hormones in the
development of anorexia and cachexia, with a focus on the neuronal control
of cachexia via the gut-brain axis,
- Understanding metabolic crosstalk mechanisms and alterations in cancer
cachexia through patient-based follow-up studies
- Conducting multi-organ integrative studies on cancer cachexia using animal
models and patient data to explore inter- and intra-tissue crosstalk,
examining the Impact of cancer treatments (chemotherapy, radiation,
immunotherapy) on cancer cachexia and its management
- Investigating novel therapeutic interventions and the potential for drug
repurposing in the treatment of cancer-related cachexia.
|
| Cancer Pain | - Clinico-biology of Pain Modulation in Chronic Cancer Pain- Studies on
interactions among brain regions that influence pain perception's affective
and cognitive dimensions
- Newer non-opioids for chronic cancer pain – development of potential new
molecules that could effectively target chronic cancer pain of mixed origin.
- Strategy for a comprehensive evaluation that integrates clinical
assessments, Cognitive-psychological social and spiritual evaluation,
biological markers, and machine learning approaches to effectively assess
chronic pain within a cancer context
- Integrative Medicine Approach for Multimodal Management of Chronic
Cancer Pain – exploration of biological factors and markers associated with
integrative therapies that contribute to pain management and strategies for
how these integrative therapies, whether individually or in combination, can
provide relief for individuals with chronic cancer pain
- Chemotherapy Induced/ Therapy induced Pain in Cancer_ addressing key
areas of chemotherapy induced peripheral neuropathy (CIPN), postoperative pain and targeted used of radiation for palliation of pain.
|
Cancer Associated Anemia | - Comprehensive research studies to understand the molecular mechanisms
driving cancer-associated anemia, particularly how cancer cells disrupt
erythroid progenitor cells and hematopoietic stem cells; crosstalk between
DNA damage response, inflammation, and aging of hematopoietic stem
cells; role of tumor-released factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GMCSF) in affecting hematopoietic stem and progenitor cells (HSPCs) etc.
- Development of targeted therapies with a focus on iron metabolism,
inflammation, and disruption of the hepcidin-ferroportin axis.
- Biomarkers for better diagnosis and monitoring anemia in cancer patients,
allowing for early intervention and more personalized treatment plans.
- Strategies to stimulate hematopoiesis, such as using erythropoiesisstimulating agents or growth factors etc. to improve red blood cell
production in cancer patients.
- Exploring combination therapies, such as pairing epigenetic inhibitors with
chemotherapy or targeting mitochondria in cancer cells, for enhancing
treatment efficacy and preventing setting in of anemia during treatment.
|
Selection Process
- Submission of EoI is indicative of your intent and in no way
guarantee funding from the Department.
- No document will be allowed to submit after deadline.
Perks of the Program
- Grants
- Work on a innovative problem.
Last Date to apply: 12 March 2025
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